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Article

Identification and characterization of yeast mutants and the gene for a cruciform cutting endonuclease.

The EMBO journal - 1 Feb 1992

Kleff S, Kemper B, Sternglanz R

Abstract excerpt

An assay was developed that detected DNA cruciform cutting endonuclease activity in crude extracts of Saccharomyces cerevisiae. A collection of temperature-sensitive strains was screened using this assay, and a mutant lacking the activity was found. The mutation leading to the enzymatic defect was mapped to the left arm of chromosome XI within 3 cM of the centromere. Cloning of the gene for this endonuclease was...

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Identifiers

PMID: 1537343
DOI: 10.1002/j.1460-2075.1992.tb05102.x
PMCID: PMC556502

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Source receipt: pubmed, retrieved 7 Sept 2026.

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