Article
Role of DRD3 in morphine-induced conditioned place preference using drd3-knockout mice.
Neuroreport - 5 Oct 2004
Francès Henriette, Le Foll Bernard, Diaz Jorge, Smirnova Maria, Sokoloff Pierre
Abstract excerpt
The dopamine D3 receptor (DRD3) mediates expression of conditioned effects of psychostimulants, but conflicting results have been obtained with opiates. In a conditioned place preference (CPP) procedure, morphine increased the time spent in a compartment previously paired with drug injection. CPP was obtained at morphine doses of 16 and 32 mg/kg in wild-type (drd3+/+) mice and 8, 16 and 32 mg/kg in DRD3-knockout...
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