Article
Intensification of the development of ethanol dependence in mice lacking dopamine D(3) receptor.
Neuroscience letters - 17 May 2002
Narita Minoru, Soma Miho, Tamaki Hiroko, Narita Michiko, Suzuki Tsutomu
Abstract excerpt
The present study was designed to ascertain the role of dopamine D3 receptors in the development of physical dependence on ethanol using mice lacking the dopamine D3 receptor gene. The mutation eliminated the dopamine D3 receptor without any detectable changes in both dopamine D1 and D2 receptors. The ethanol-induced sleep time in dopamine D3 receptor knockout mice (D3-KO) was longer than that in wild-type mice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
