Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopamine D3 receptor mutant and wild-type mice exhibit identical responses to putative D3 receptor-selective agonists and antagonists.

Synapse (New York, N.Y.) - 1 Mar 1999

Xu M, Koeltzow T E, Cooper D C, Tonegawa S, White F J

Abstract excerpt

Previous studies using a variety of drugs with different affinities for the dopamine (DA) D3 receptor suggested that this receptor is involved in regulating motor activity and hypothermia. However, the in vivo selectivity of many of these compounds has been repeatedly questioned. To examine the precise roles of the DA D3 receptor in motor activity and hypothermic responses, we used mutant mice lacking the DA D3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzopyrans
Share to Dopamine Agonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Antagonists

Share to Mice, Mutant Strains

Share to Oxazines

Share to Receptors, Dopamine D2

Share to Receptors, Dopamine D3

Share to Reference Values

Source

Identifiers

PMID: 10029239
DOI: 10.1002/(SICI)1098-2396(19990301)31:3<210::AID-SYN6>3.0.CO;2-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopamine D3 receptor mutant and wild-type mice exhibit identical responses to putative D3 receptor-selective agonists and antagonists.PMID 10029239Read ↗

7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment.Semantic proximity Read ↗

Locomotor activity induced by MK-801 is enhanced in dopamine D3 receptor knockout mice but suppression by dopamine D3/D2 antagonists does not occur through the dopamine D3 receptor.Semantic proximity Read ↗

Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors.Semantic proximity Read ↗

Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors.Semantic proximity Read ↗

Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors.Semantic proximity Read ↗

Dopamine D3 receptor knockout mice and the motivational effects of ethanol.Semantic proximity Read ↗

Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout".Semantic proximity Read ↗

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.Semantic proximity Read ↗

Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesiaSemantic proximity Read ↗

Role of dopamine D(1) receptors for kappa-opioid-mediated locomotor activity and antinociception during the preweanling period: a study using D(1) receptor knockout mice.Semantic proximity Read ↗

D1-like dopamine receptor-mediated function in congenic mutants with D1 vs. D5 receptor "knockout".Semantic proximity Read ↗

Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.