Article
Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016
Hunegnaw Ruth, Vassylyeva Marina, Dubrovsky Larisa, Pushkarsky Tatiana, Sviridov Dmitri, Anashkina Anastasia A, Üren Aykut, Brichacek Beda, Vassylyev Dmitry G, Adzhubei Alexei A, Bukrinsky Michael
Abstract excerpt
OBJECTIVE: HIV-infected patients are at an increased risk of developing atherosclerosis, in part because of downmodulation and functional impairment of ATP-binding cassette A1 (ABCA1) cholesterol transporter by the HIV-1 protein Nef. The mechanism of this effect involves Nef interacting with an ER chaperone calnexin and disrupting calnexin binding to ABCA1, leading to ABCA1 retention in ER, its degradation and...
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