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Article

Targeting a Novel RNA-Protein Interaction for Therapeutic Intervention of Hantavirus Disease

13 Oct 2016

Abstract excerpt

An evolutionarily conserved sequence at the 5' terminus of hantaviral genomic RNA plays an important role in viral transcription initiation and packaging of the viral genome into viral nucleocapsids. Interaction of viral nucleocapsid protein (N) with this conserved sequence facilitates mRNA translation by a unique N-mediated translation strategy. Whereas this evolutionarily conserved sequence facilitates virus...

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PMID: 27733686
DOI: 10.1074/jbc.m116.750729

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