Article
C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter.
The Journal of biological chemistry - 9 Dec 2005
Racek Tomás, Mise Nikica, Li Zhenpeng, Stoll Anja, Pützer Brigitte M
Abstract excerpt
Activation of telomerase is linked to tumorigenesis and has been observed in a variety of human tumors. Previous reports demonstrated that p53 represses human telomerase reverse transcriptase (hTERT), a key component for telomerase activity. The p73 protein displays a tumor suppressor activity similar to p53. In the present study, we examined the effect of transactivation competent p73 isoforms on hTERT...
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