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Article

Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2000

Kanaya T, Kyo S, Hamada K, Takakura M, Kitagawa Y, Harada H, Inoue M

Abstract excerpt

Telomerase activation is a critical step in cellular immortality and oncogenesis. The activity of telomerase is known to be correlated with cell proliferation, but its regulation by cell cycle regulators is not well understood. In the present study, we examined the effects of p53 on telomerase activity. Wild-type p53 was introduced into SiHa cells via a recombinant adenoviral vector, Ad5CMV-p53, and change in...

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PMID: 10778946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.PMID 10778946Read ↗

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