Article
Estimation of allele frequency and association mapping using next-generation sequencing data.
BMC bioinformatics - 11 Jun 2011
Kim Su Yeon, Lohmueller Kirk E, Albrechtsen Anders, Li Yingrui, Korneliussen Thorfinn, Tian Geng, Grarup Niels, Jiang Tao, Andersen Gitte, Witte Daniel, Jorgensen Torben, Hansen Torben, Pedersen Oluf, Wang Jun, Nielsen Rasmus
Abstract excerpt
BACKGROUND: Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing, a cost effective approach is to use medium or low-coverage data (e.g., < 15X). However, SNP calling and allele frequency estimation in such studies is associated with substantial statistical uncertainty because of varying coverage and...
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