Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase.

Genetics - 1 Jan 2005

Shanower Gregory A, Muller Martin, Blanton Jason L, Honti Viktor, Gyurkovics Henrik, Schedl Paul

Abstract excerpt

We have identified a novel gene named grappa (gpp) that is the Drosophila ortholog of the Saccharomyces cerevisiae gene Dot1, a histone methyltransferase that modifies the lysine (K)79 residue of histone H3. gpp is an essential gene identified in a genetic screen for dominant suppressors of pairing-dependent silencing, a Polycomb-group (Pc-G)-mediated silencing mechanism necessary for the maintenance phase of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to Gene Silencing
Share to Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Lysine

Share to Methylation

Share to Polycomb Repressive Complex 1

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 15371351
DOI: 10.1534/genetics.104.033191
PMCID: PMC1448877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase.PMID 15371351Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.Semantic proximity Read ↗

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.Semantic proximity Read ↗

Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.Semantic proximity Read ↗

DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.Semantic proximity Read ↗

Dot1p modulates silencing in yeast by methylation of the nucleosome core.Semantic proximity Read ↗

Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.Semantic proximity Read ↗

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.Semantic proximity Read ↗

Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Semantic proximity Read ↗

Molecular genetic analysis of Chd3 and polytene chromosome region 76B-D in Drosophila melanogaster.Semantic proximity Read ↗

Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.Semantic proximity Read ↗

A comprehensive HA-tagged PRC1 toolkit enables standardized chromatin profiling and proteomic analysis in Drosophila melanogasterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.