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Article

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2010

Siebold Alex P, Banerjee Rakhee, Tie Feng, Kiss Daniel L, Moskowitz Jacob, Harte Peter J

Abstract excerpt

Polycomb Group (PcG) and Trithorax Group (TrxG) proteins are key epigenetic regulators of global transcription programs. Their antagonistic chromatin-modifying activities modulate the expression of many genes and affect many biological processes. Here we report that heterozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lysine 27 (H3K27)-specific methyltransferase E(Z)...

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Identifiers

PMID: 20018689
DOI: 10.1073/pnas.0907739107
PMCID: PMC2806727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.PMID 20018689Read ↗

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