Article
Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus.
Gastroenterology - 1 Oct 2012
Park Su-Hyung, Shin Eui-Cheol, Capone Stefania, Caggiari Laura, De Re Valli, Nicosia Alfredo, Folgori Antonella, Rehermann Barbara
Abstract excerpt
BACKGROUND & AIMS: T cells are an important component for development of a vaccine against hepatitis C virus (HCV), but little is known about the features of successful vaccine-induced T cells. METHODS: We compared the phenotype, function, and kinetics of vaccine-induced and infection-induced T cells in chimpanzees with HCV infection using multicolor flow cytometry and real-time polymerase chain reaction....
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