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Article

Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.

Disease models & mechanisms - 1 May 2014

Brennan Tracy A, Egan Kevin P, Lindborg Carter M, Chen Qijun, Sweetwyne Mariya T, Hankenson Kurt D, Xie Sharon X, Johnson Frederick B, Pignolo Robert J

Abstract excerpt

A major medical challenge in the elderly is osteoporosis and the high risk of fracture. Telomere dysfunction is a cause of cellular senescence and telomere shortening, which occurs with age in cells from most human tissues, including bone. Telomere defects contribute to the pathogenesis of two progeroid disorders characterized by premature osteoporosis, Werner syndrome and dyskeratosis congenital. It is...

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Identifiers

PMID: 24626990
DOI: 10.1242/dmm.014928
PMCID: PMC4007409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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