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Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro

27 Mar 2008

Abstract excerpt

Stanniocalcin 1 (STC1) and STC2 are secreted, homodimeric glycoproteins that share 30% amino acid sequence identity. Breast tumour gene profiling studies have demonstrated significantly upregulated STC2 expression in hormone-responsive positive breast tumours; therefore, the purpose of this study was to investigate STC2 hormonal regulation and function in breast cancer cells. Here we report that STC2 is expressed...

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PMID: 18492817
DOI: 10.1677/joe-08-0043

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