Article

Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxia

2025-10-16

Abstract excerpt

In response to hypoxia, animals reduce somatic growth to shift energy resources toward the maintenance of vital functions and survival. Although this phenomenon is widespread in the animal kingdom, the factors and mechanisms involved remain poorly understood. Here we report that hypoxia causes major changes in zebrafish transcriptomic landscapes with hormonal activity or hormonal signaling identified as most promi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce05a711-8138-5ba5-bbd2-a45cb6fc4a69
DOI: 10.1101/2025.10.16.682858

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxiaDOI 10.1101/2025.10.16.682858Read

Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis.Semantic proximity Read

Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.Semantic proximity Read

Zebrafish IGF Genes: Gene Duplication, Conservation and Divergence, and Novel Roles in Midline and Notochord DevelopmentSemantic proximity Read

Sexual dimorphic effects of igf1 deficiency on metabolism in zebrafishSemantic proximity Read

Molecular Cloning, Bioinformatics Analysis and Expression of Insulin-Like Growth Factor 2 from Tianzhu White Yak, Bos grunniensSemantic proximity Read

Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism.Semantic proximity Read

Essential roles of stat5.1/stat5b in controlling fish somatic growth.Semantic proximity Read

CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.Semantic proximity Read

Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression.Semantic proximity Read

Mutation of spexin2 promotes feeding, somatic growth, adiposity, and insulin resistance in zebrafish.Semantic proximity Read

A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1).Semantic proximity Read

CircCOPS8 inhibits the proliferation of buffalo myoblasts by binding to IGF2BP3 and promoting tumor suppressor gene expressionSemantic proximity Read