Article
Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice.
Endocrinology - 1 Mar 2002
Varghese Robin, Gagliardi Anthony D, Bialek Peter E, Yee Siu-Pok, Wagner Graham F, Dimattia Gabriel E
Abstract excerpt
In mammals stanniocalcin (STC) is widely expressed, and in the kidney and gut it regulates serum calcium levels by promoting phosphate reabsorption. To shed further light on its functional significance in mammals we have created several lines of mice that express a human STC (hSTC) transgene. Three lines expressed the hSTC transgene, but only two lines exhibited high expression and contained circulating hSTC, and...
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