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Article

Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis.

The Journal of biological chemistry - 6 Feb 2015

Jepsen Malene R, Kløverpris Søren, Mikkelsen Jakob H, Pedersen Josefine H, Füchtbauer Ernst-Martin, Laursen Lisbeth S, Oxvig Claus

Abstract excerpt

Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues. However, although transgenic expression in mice is known to cause severe dwarfism, and targeted deletion of STC2 causes increased postnatal growth, its precise biological role is still unk...

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Identifiers

PMID: 25533459
DOI: 10.1074/jbc.M114.611665
PMCID: PMC4319012

Genes

STC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25533459-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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