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Article

TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1.

Frontiers in immunology - 1 Jan 2022

Akagi Takahiko, Hiramatsu-Asano Sumie, Ikeda Kenta, Hirano Hiroyasu, Tsuji Shoko, Yahagi Ayano, Iseki Masanori, Matsuyama Makoto, Mak Tak W, Nakano Kazuhisa, Ishihara Katsuhiko, Morita Yoshitaka, Mukai Tomoyuki

Abstract excerpt

Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory periodic fever syndrome associated with heterozygous mutations in TNFRSF1A, which encodes TNF receptor type I (TNFR1). Although possible proinflammatory mechanisms have been proposed, most previous studies were performed using in vitro overexpression models, which could lead to undesirable inflammatory responses due...

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Identifiers

PMID: 35936010
DOI: 10.3389/fimmu.2022.926175
PMCID: PMC9355097

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