Article
PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2006
Rutschmann Sophie, Hoebe Kasper, Zalevsky Jonathan, Du Xin, Mann Navjiwan, Dahiyat Bassil I, Steed Paul, Beutler Bruce
Abstract excerpt
A dominant hypomorphic allele of Tnf, PanR1, was identified in a population of G(1) mice born to N-ethyl-N-nitrosourea-mutagenized sires. Macrophages from homozygotes produced no detectable TNF bioactivity, although normal quantities of immunoreactive TNF were secreted. The phenotype was confined to a critical region on mouse chromosome 17, and then ascribed to a C-->A transversion at position 3480 of the Tnf...
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