Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rb and N-ras function together to control differentiation in the mouse.

Molecular and cellular biology - 1 Aug 2003

Takahashi Chiaki, Bronson Roderick T, Socolovsky Merav, Contreras Bernardo, Lee Kwang Youl, Jacks Tyler, Noda Makoto, Kucherlapati Raju, Ewen Mark E

Abstract excerpt

The product of the retinoblastoma tumor suppressor gene (Rb) can control cell proliferation and promote differentiation. Murine embryos nullizygous for Rb die midgestation with defects in cell cycle regulation, control of apoptosis, and terminal differentiation of several tissues, including skeletal muscle, nervous system, and lens. Previous cell culture-based experiments have suggested that the retinoblastoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Genes, ras

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to MyoD Protein

Share to ras Proteins

Share to Retinoblastoma Protein

Share to S Phase

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 12861012
DOI: 10.1128/MCB.23.15.5256-5268.2003
PMCID: PMC165732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rb and N-ras function together to control differentiation in the mouse.PMID 12861012Read ↗

Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation.Semantic proximity Read ↗

The retinoblastoma protein is linked to the activation of Ras.Semantic proximity Read ↗

RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.Semantic proximity Read ↗

The retinoblastoma gene: role in cell cycle control and cell differentiationSemantic proximity Read ↗

Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.Semantic proximity Read ↗

RB, the conductor that orchestrates life, death and differentiation.Semantic proximity Read ↗

MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesisSemantic proximity Read ↗

Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.Semantic proximity Read ↗

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos.Semantic proximity Read ↗

SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle developmentSemantic proximity Read ↗

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.Semantic proximity Read ↗

K-ras is an essential gene in the mouse with partial functional overlap with N-ras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.