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Article

SMAD2 promotes myogenin expression and terminal myogenic differentiation

18 Jan 2021

Abstract excerpt

ABSTRACT SMAD2 is a transcription factor, the activity of which is regulated by members of the transforming growth factor β (TGFβ) superfamily. Although activation of SMAD2 and SMAD3 downstream of TGFβ or myostatin signaling is known to inhibit myogenesis, we found that SMAD2 in the absence of TGFβ signaling promotes terminal myogenic differentiation. We found that, during myogenic differentiation, SMAD2...

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PMID: 33462116
DOI: 10.1242/dev.195495

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