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Article

Phosphorylation of pRb is required for HGF-induced muscle cell proliferation and is p27kip1-dependent.

Journal of cellular physiology - 1 May 2002

Leshem Yael, Halevy Orna

Abstract excerpt

Hepatocyte growth factor (HGF) plays a crucial role in the differentiation of skeletal muscle cells, where a process in which the retinoblastoma protein (pRb) has been implicated. We addressed the role of pRb in HGF-mediated effects on the proliferation and differentiation of adult skeletal muscle myoblasts. HGF shifted pRb to its hyperphosphorylation forms and increased the transactivation of E2F1, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12064460
DOI: 10.1002/jcp.10089

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of pRb is required for HGF-induced muscle cell proliferation and is p27kip1-dependent.PMID 12064460Read ↗

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