Article
Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered.
Clinical and diagnostic laboratory immunology - 1 Sept 2004
Zaman Munir M, Gelrud Andres, Junaidi Omer, Regan Meredith M, Warny Michel, Shea Julie C, Kelly Ciaran, O'Sullivan Brian P, Freedman Steven D
Abstract excerpt
Patients with cystic fibrosis (CF) exhibit an excessive host inflammatory response. The aim of this study was to determine (i) whether interleukin 8 (IL-8) secretion is increased from monocytes from subjects heterozygous as well as homozygous for cystic fibrosis transmembrane conductance regulator (CFTR) mutations and (ii) whether this is due to increased cell surface lipopolysaccharide (LPS) receptors or,...
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