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Article

CYP2C9 and VKORC1 polymorphisms influence warfarin dose variability in patients on long-term anticoagulation.

European journal of clinical pharmacology - 1 Apr 2013

Santos Paulo Caleb Junior Lima, Dinardo Carla Luana, Schettert Isolmar Tadeu, Soares Renata Alonso Gadi, Kawabata-Yoshihara Liz, Bensenor Isabela Martins, Krieger José Eduardo, Lotufo Paulo Andrade, Pereira Alexandre Costa

Abstract excerpt

OBJECTIVES: The main aim of this study was to determine whether CYP2C9 and VKORC1 polymorphisms influence warfarin dose variability during initial dose-finding phase and during maintenance treatment after 360 days. METHODS: Two hundred and six consecutive patients who were beginning warfarin therapy were selected. They were assessed for general and clinical characteristics; prescribed warfarin dose; response to...

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Share to Anticoagulants
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Coagulation

Share to Cytochrome P-450 CYP2C9

Share to Dose-Response Relationship, Drug

Share to Mixed Function Oxygenases

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 22990331
DOI: 10.1007/s00228-012-1404-5

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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