Article
The c.-1639G>A polymorphism of the VKORC1 gene in Serbian population: retrospective study of the variability in response to oral anticoagulant therapy.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2010
Kovac Mirjana K, Maslac Aleksandar R, Rakicevic Ljiljana B, Radojkovic Dragica P
Abstract excerpt
A single nucleotide polymorphism c.-1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral vitamin K antagonist (VKA). Our aim was to study the effect of c.-1639G>A polymorphism on the acenocoumarol dosage requirements in a group of patients under stable anticoagulation, and to estimate the variability in response to...
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