The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects.

doi:10.1038/sj.bjp.0704588

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Article

The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects.

British journal of pharmacology - 1 Mar 2002

Krobert Kurt A, Levy Finn Olav

Abstract excerpt

1. Using membranes from stably or transiently transfected HEK293 cells cultured in 5-HT-free medium and expressing the recombinant human 5-HT(7) receptor splice variants (h5-HT(7(a)), h5-HT(7(b)) and h5-HT(7(d))), we compared their abilities to constitutively activate adenylyl cyclase (AC). 2. All h5-HT(7) splice variants elevated basal and forskolin-stimulated AC. The basal AC activity was reduced by the 5-HT(7)...

Topics

Adenylyl Cyclase Inhibitors
Adenylyl Cyclases
Alternative Splicing
Cell Line
Dose-Response Relationship, Drug
Genetic Variation
Humans
Receptors, Serotonin
Serotonin Antagonists
Serotonin Receptor Agonists
Transfection

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Identifiers

PMID: 11906971
DOI: 10.1038/sj.bjp.0704588
PMCID: PMC1573253

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