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Article

Multiple phosphorylation sites are required for pathway-selective uncoupling of the 5-hydroxytryptamine1A receptor by protein kinase C.

Molecular pharmacology - 1 Dec 1995

Lembo P M, Albert P R

Abstract excerpt

Classically, acute uncoupling of G protein-linked receptors has been presented as a nonselective process in which modification of the receptor by phosphorylation leads to reduction in or the loss of coupling to all effectors. Investigation of multiple signaling pathways has modified this view: for example, when expressed in Ltk- fibroblasts, the 5-hydroxytryptamine 1A (5-HT1A) receptor couples to both stimulation...

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PMID: 8848001

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