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Article

Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.

Cancer chemotherapy and pharmacology - 1 Nov 2005

Yawata Ayako, Kim Su-Ryang, Miyajima Atsuko, Kubo Takashi, Ishida Seiichi, Saito Yoshiro, Nakajima Yukiko, Katori Noriko, Matsumoto Yoshiaki, Fukuoka Masamichi, Ohno Yasuo, Ozawa Shogo, Sawada Jun-Ichi

Abstract excerpt

PURPOSE: Thymidylate synthase (TS) is one of the target molecules for the antitumor effects of fluoropyrimidine drugs. The cellular thymidylate synthase level is one of the determining factors for the antitumor activity of fluoropyrimidines. TYMS, which encodes TS, has been reported to possess 28-bp tandem repeat sequences in its 5'-untranslated region, the number of which varies. In addition, single nucleotide...

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Share to Antimetabolites, Antineoplastic
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Fluorouracil

Share to Gene Expression Regulation, Enzymologic

Share to Luciferases

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Source

Identifiers

PMID: 15918040
DOI: 10.1007/s00280-005-1018-z

Genes

TYMS
DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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