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Article

Circulating Growth Factor Levels Are Associated with Tumorigenesis in Neurofibromatosis Type 1

1 Sept 2004

Abstract excerpt

PURPOSE: Neurofibromatosis type 1 (NF1) is characterized by systemic development of neurofibromas. Early clinical diagnosis can be ambiguous, and genetic diagnosis can be prohibitively difficult. Dysregulation of a number of growth factors has been suggested to be a mechanism of pathogenesis. This study was performed to assess the contribution of circulating growth factors for diffuse tumorigenesis and the...

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PMID: 15355893
DOI: 10.1158/1078-0432.ccr-03-0769

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