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Article

NF1 mutation-driven neuronal hyperexcitability sets a threshold for tumorigenesis and therapeutic targeting of murine optic glioma.

Neuro-oncology - 5 Aug 2024

Anastasaki Corina, Chatterjee Jit, Koleske Joshua P, Gao Yunqing, Bozeman Stephanie L, Kernan Chloe M, Marco Y Marquez Lara I, Chen Ji-Kang, Kelly Caitlin E, Blair Connor J, Dietzen Dennis J, Kesterson Robert A, Gutmann David H

Abstract excerpt

BACKGROUND: With the recognition that noncancerous cells function as critical regulators of brain tumor growth, we recently demonstrated that neurons drive low-grade glioma initiation and progression. Using mouse models of neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG), we showed that Nf1 mutation induces neuronal hyperexcitability and midkine expression, which activates an immune axis to...

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Identifiers

PMID: 38607967
DOI: 10.1093/neuonc/noae054
PMCID: PMC11300021

Genes

NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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