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Article

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.

Human molecular genetics - 1 Jun 2006

Munchhof Amy M, Li Fang, White Hilary A, Mead Laura E, Krier Theresa R, Fenoglio Amy, Li Xiaohong, Yuan Jin, Yang Feng-Chun, Ingram David A

Abstract excerpt

Genetic inactivation of tumor suppressor genes initiates human cancers. However, interaction of accessory cells with the tumor-initiating cell within the microenvironment is often required for tumor progression. This paradigm is relevant to understanding neurofibroma development in neurofibromatosis type I patients. Somatic inactivation of the Nf1 tumor suppressor gene, which encodes neurofibromin, is necessary...

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PMID: 16648142
DOI: 10.1093/hmg/ddl108

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