Variations in HIV-1 pol gene associated with reduced sensitivity to antiretroviral drugs in treatment-naive patients.

doi:10.1097/00002030-199818000-00005

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Article

Variations in HIV-1 pol gene associated with reduced sensitivity to antiretroviral drugs in treatment-naive patients.

AIDS (London, England) - 24 Dec 1998

Birk M, Sönnerborg A

Abstract excerpt

OBJECTIVE: Various drugs against the HIV-1 enzymes reverse transcriptase (RT) and protease have been introduced in the last few years: protease inhibitors, nucleoside RT inhibitors (NRTI) and non-NRTI (NNRTI). Several sequence variations associated with reduced drug sensitivity have been described in the HIV-1 pol gene. DESIGN: To analyse the occurrence of mutations associated with drug resistance in...

Topics

Adolescent
Adult
Anti-HIV Agents
Drug Resistance, Microbial
Endopeptidases
Female
Genes, pol
HIV Infections
HIV Protease Inhibitors
HIV Reverse Transcriptase
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

RNA

Reverse Transcriptase Inhibitors

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 9875574
DOI: 10.1097/00002030-199818000-00005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9875574-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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