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Article

A temperature-sensitive disorder in basal transcription and DNA repair in humans.

Nature genetics - 1 Mar 2001

Vermeulen W, Rademakers S, Jaspers N G, Appeldoorn E, Raams A, Klein B, Kleijer W J, Hansen L K, Hoeijmakers J H

Abstract excerpt

The xeroderma pigmentosum group D (XPD) helicase subunit of TFIIH functions in DNA repair and transcription initiation. Different mutations in XPD give rise to three ultraviolet-sensitive syndromes: the skin cancer-prone disorder xeroderma pigmentosum (XP), in which repair of ultraviolet damage i...

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Identifiers

PMID: 11242112
DOI: 10.1038/85864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11242112-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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