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Article

Dysfunctional proofreading in the Escherichia coli DNA polymerase III core.

The Biochemical journal - 1 Dec 2004

Lehtinen Duane A, Perrino Fred W

Abstract excerpt

The epsilon-subunit contains the catalytic site for the 3'-->5' proofreading exonuclease that functions in the DNA pol III (DNA polymerase III) core to edit nucleotides misinserted by the alpha-subunit DNA pol. A novel mutagenesis strategy was used to identify 23 dnaQ alleles that exhibit a mutator phenotype in vivo. Fourteen of the epsilon mutants were purified, and these proteins exhibited 3'-->5' exonuclease...

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Identifiers

PMID: 15352874
DOI: 10.1042/BJ20040660
PMCID: PMC1134117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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