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Article

Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice.

Biochemical and biophysical research communications - 8 Oct 2004

Nakada Kazuto, Sato Akitsugu, Sone Hideyuki, Kasahara Atsuko, Ikeda Katsuhisa, Kagawa Yasuo, Yonekawa Hiromichi, Hayashi Jun-Ichi

Abstract excerpt

Mito-mice carrying various proportions of deletion mutant mtDNA (DeltamtDNA) were generated by introduction of the DeltamtDNA from cultured cells into fertilized eggs of C57BL/6J (B6) strain mice. Great advantages of mito-mice are that they share exactly the same nuclear-genome background, and that their genetic variations are restricted to proportions of pathogenic DeltamtDNA. Since accumulation of DeltamtDNA to...

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PMID: 15351718
DOI: 10.1016/j.bbrc.2004.08.073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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