Article
Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.
Hearing research - 1 Apr 2007
Yamasoba Tatsuya, Someya Shinichi, Yamada Chikako, Weindruch Richard, Prolla Tomas A, Tanokura Masaru
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during aging and showed accelerated aging primarily due to increased apoptosis. They exhibited moderate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.