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Article

Novel mutations that control the sphingolipid and cholesterol dependence of the Semliki Forest virus fusion protein.

Journal of virology - 1 Dec 2002

Chatterjee Prodyot K, Eng Christina H, Kielian Margaret

Abstract excerpt

The enveloped alphavirus Semliki Forest virus (SFV) infects cells via a membrane fusion reaction mediated by the E1 membrane protein. Efficient SFV-membrane fusion requires the presence of cholesterol and sphingolipid in the target membrane. Here we report on two mutants, srf-4 and srf-5, selected for growth in cholesterol-depleted cells. Like the previously isolated srf-3 mutant (E1 proline 226 to serine), the...

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Identifiers

PMID: 12438597
DOI: 10.1128/jvi.76.24.12712-12722.2002
PMCID: PMC136714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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