Article
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Friso Simonetta, Choi Sang-Woon, Girelli Domenico, Mason Joel B, Dolnikowski Gregory G, Bagley Pamela J, Olivieri Oliviero, Jacques Paul F, Rosenberg Irwin H, Corrocher Roberto, Selhub Jacob
Abstract excerpt
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by methyltransferases that use the universal methyl donor S-adenosyl-l-methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for synthesis of methionine from homocysteine and precursor of...
Topics
- Adult
- Aged
- Coronary Artery Disease
- DNA Methylation
- Female
- Folic Acid
- Genotype
- Homozygote
- Humans
- Male