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Article

Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases.

Molecular cell - 10 Sept 2004

Ghosh Agnidipta, Uthaiah Revathy, Howard Jonathan, Herrmann Christian, Wolf Eva

Abstract excerpt

Interferon-inducible p47 GTPases are critical mediators of cell-autonomous resistance against several intracellular pathogens. Here we present the first crystal structure of a member of this novel GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form. The structure shows a Ras-like G domain between an N-terminal three-helix bundle and a complex system of C-terminal helices and loops. Sequence...

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Source

Identifiers

PMID: 15350217
DOI: 10.1016/j.molcel.2004.07.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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