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Article

The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion.

BMC biology - 2 Mar 2016

Schulte Kathrin, Pawlowski Nikolaus, Faelber Katja, Fröhlich Chris, Howard Jonathan, Daumke Oliver

Abstract excerpt

BACKGROUND: The immunity-related GTPases (IRGs) constitute a powerful cell-autonomous resistance system against several intracellular pathogens. Irga6 is a dynamin-like protein that oligomerizes at the parasitophorous vacuolar membrane (PVM) of Toxoplasma gondii leading to its vesiculation. Based on a previous biochemical analysis, it has been proposed that the GTPase domains of Irga6 dimerize in an antiparallel...

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Identifiers

PMID: 26934976
DOI: 10.1186/s12915-016-0236-7
PMCID: PMC4774019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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