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Crystal structure of a novel guanine nucleotide exchange factor encoded by the scrub typhus pathogen <i>Orientia tsutsugamushi</i>

2020-06-04

Abstract excerpt

Rho family GTPases regulate an array of cellular processes and are often modulated by pathogens to promote infection. Here, we identify a cryptic guanine nucleotide exchange factor (GEF) domain in the OtDUB protein encoded by the pathogenic bacterium Orientia tsutsugamushi . A proteomics-based OtDUB interaction screen identified numerous potential host interactors, including the Rho-GTPases Rac1 and Cdc42. We dis...

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Literature Corpus work
a170a4fa-aa7e-5eb7-af6c-e12b79c4d2ca
DOI
10.1101/2020.06.04.133876
Open publication

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Crystal structure of a novel guanine nucleotide exchange factor encoded by the scrub typhus pathogen <i>Orientia tsutsugamushi</i>DOI 10.1101/2020.06.04.133876
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