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Article

DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast.

The Journal of biological chemistry - 5 Nov 2004

Sugimoto Izumi, Murakami Hiroshi, Tonami Yuko, Moriyama Akihiko, Nakanishi Makoto

Abstract excerpt

The relationship between the DNA replication and spindle checkpoints of the cell cycle is unclear, given that in most eukaryotes, spindle formation occurs only after DNA replication is complete. Fission yeast rad3 mutant cells, which are deficient in DNA replication checkpoint function, enter, progress through, and exit mitosis even when DNA replication is blocked. In contrast, the entry of cds1 mutant cells into...

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PMID: 15347659
DOI: 10.1074/jbc.M403231200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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