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Article

Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus.

The Journal of antimicrobial chemotherapy - 1 Oct 2004

Meka Venkata G, Gold Howard S, Cooke Amy, Venkataraman Lata, Eliopoulos George M, Moellering Robert C, Jenkins Stephen G

Abstract excerpt

OBJECTIVES: Linezolid resistance in rare isolates of Staphylococcus aureus has been associated with G2576T mutations in domain V of the 23S rRNA gene. We report the analysis of a clinical S. aureus isolate that developed linezolid resistance (MIC of linezolid of 12 mg/L) after a 25 day course of the drug. Sequencing identified G2576T mutations in four of the five copies of the 23S rRNA gene. METHODS: To examine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15347637
DOI: 10.1093/jac/dkh423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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