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A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidis

9 May 2009

Abstract excerpt

Sir, Linezolid is an important antimicrobial agent for the treatment of infections caused by Gram-positive organisms, including methicillin-resistant staphylococci. The mechanism of action is thought to involve the inhibition of protein synthesis through binding to the domain V region of 23S rRNA. Until now, the G2576T and T2500A mutations in the domain V region of the 23S rRNA gene (Escherichia coli 23S rRNA...

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PMID: 19429927
DOI: 10.1093/jac/dkp167

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A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidisPMID 19429927Read ↗

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