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Article

Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination.

PloS one - 1 Jan 2016

Iguchi Shigekazu, Mizutani Tomonori, Hiramatsu Keiichi, Kikuchi Ken

Abstract excerpt

BACKGROUND: We previously reported the case of a 64-year-old man with mediastinitis caused by Staphylococcus aureus in which the infecting bacterium acquired linezolid resistance after only 14 days treatment with linezolid. We therefore investigated relevant clinical isolates for possible mechanisms of this rapid acquisition of linezolid resistance. METHODS: Using clinical S. aureus isolates, we assessed the in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27182700
DOI: 10.1371/journal.pone.0155512
PMCID: PMC4868352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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