Article
Comprehensive analysis of genetic polymorphisms in the interleukin-10 promoter: implications for immune regulation in specific ethnic populations.
Genetic testing - 1 Jan 2004
Rady Peter L, Matalon Reuben, Grady James, Smith Eric M, Hudnall S David, Kellner Leonard H, Nitowsky Harold, Tyring Stephen K, Hughes Thomas K
Abstract excerpt
The association of interleukin-10 (IL-10) promoter single-nucleotide polymorphisms (SNPs) as risk factors for certain inflammatory diseases, viral infections, cancers, and transplant rejection have been the subject of recent studies. The SNPs -1082 G --> A, -819 C --> T, and -592 C --> A, which have been associated with differential IL-10 production, are strongly linked with ethnicity. In this study, we...
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