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Article

[Degradation of Cdc25A phosphatase in HeLa cells under normal and stress conditions].

Tsitologiia - 1 Jan 2004

Goloudina A R, Aksenov N D, Pospelov V A

Abstract excerpt

Cdc25A phosphatase regulates cell cycle progression by removing the inhibitory phosphates from cyclin-dependent kinases. Activity of Cdc25A depends on its phosphorylation status. During normal cell cycle progression and after DNA damage phosphorylation by Chk1 (or Chk2) triggers Cdc25A degradation via ubiquitin-proteasome pathway. In this study we investigate the role of various phosphorylation sites (Ser123,...

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Identifiers

PMID: 15344887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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