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Article

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.

The Journal of biological chemistry - 19 Nov 2004

Taira Kiyohito, Umikawa Masato, Takei Kimiko, Myagmar Bat-Erdene, Shinzato Manabu, Machida Noriko, Uezato Hiroshi, Nonaka Shigeo, Kariya Ken-ichi

Abstract excerpt

Rap2 belongs to the Ras family of small GTP-binding proteins, but its specific roles in cell signaling remain unknown. In the present study, we have affinity-purified from rat brain a Rap2-interacting protein of approximately 155 kDa, p155. By liquid chromatography tandem mass spectrometry, we have identified p155 as Traf2- and Nck-interacting kinase (TNIK). TNIK possesses an N-terminal kinase domain homologous...

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PMID: 15342639
DOI: 10.1074/jbc.M406370200

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TNIK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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