Article
The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.
The Journal of experimental medicine - 17 Oct 2016
Roncagalli Romain, Cucchetti Margot, Jarmuzynski Nicolas, Grégoire Claude, Bergot Elise, Audebert Stéphane, Baudelet Emilie, Menoita Marisa Goncalves, Joachim Anais, Durand Stéphane, Suchanek Miloslav, Fiore Frédéric, Zhang Lichen, Liang Yinming, Camoin Luc, Malissen Marie, Malissen Bernard
Abstract excerpt
The RLTPR cytosolic protein, also known as CARMIL2, is essential for CD28 co-stimulation in mice, but its importance in human T cells and mode of action remain elusive. Here, using affinity purification followed by mass spectrometry analysis, we showed that RLTPR acts as a scaffold, bridging CD28 to the CARD11/CARMA1 cytosolic adaptor and to the NF-κB signaling pathway, and identified proteins not found before...
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