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Article

Genetic suppression of intronic +1G mutations by compensatory U1 snRNA changes in Caenorhabditis elegans.

Genetics - 1 Aug 2004

Zahler Alan M, Tuttle John D, Chisholm Andrew D

Abstract excerpt

Mutations to the canonical +1G of introns, which are commonly found in many human inherited disease alleles, invariably result in aberrant splicing. Here we report genetic findings in C. elegans that aberrant splicing due to +1G mutations can be suppressed by U1 snRNA mutations. An intronic +1G-to-U mutation, e936, in the C. elegans unc-73 gene causes aberrant splicing and loss of gene function. We previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15342508
DOI: 10.1534/genetics.104.028746
PMCID: PMC1471001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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